Anti-obesity medication and weight loss drugs are pharmacological mediators which lessen or control weight. These drugs modify one of the central processes of the human body or weight regulation by varying either appetite or absorption of calories. The treatment modalities for overweight and obese individuals remain dieting and physical exercise. Because the human body uses various chemicals and hormones to protect its stores of fat reaction probably useful to our ancestors when food was scarce in the past. The supreme anti-obesity drug would produce sustained weight loss with minimal side effects. The mechanisms that control energy balance have substantial built-in redundancy, overlap considerably with other physiological functions, and are influenced by social, hedonic and psychological factors that limit the effectiveness of pharmacological interventions.